Nies A S, Melmon K L
Calif Med. 1967 May;106(5):388-99.
As yet, no perfect drug has been found which can reduce supine and standing blood pressure equally, alter primarily peripheral vascular resistance, increase flow to the kidneys and be free of untoward effects. The thiazides, which act directly on the vessels and alpha methyl dopa, which causes an incomplete sympathetic blockade, are the two agents which come closest to the ideal. The advances which have resulted from the discovery of the false neurotransmitters may be expected to lead to the discovery of non-toxic drugs which cause subtle changes in the nerve ending and more controlled sympathetic blockade.
到目前为止,尚未发现一种能同时同等程度降低仰卧位和站立位血压、主要改变外周血管阻力、增加肾血流量且无不良作用的理想药物。直接作用于血管的噻嗪类药物和引起不完全交感神经阻滞的α-甲基多巴,是最接近理想状态的两种药物。假神经递质的发现所带来的进展,有望促使人们发现能引起神经末梢细微变化且交感神经阻滞更可控的无毒药物。