Gouyon J B, Thonney M, Guignard J P
Laboratoire de Néphrologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Suisse.
Biol Neonate. 1991;59(6):358-62. doi: 10.1159/000243372.
Renal hemodynamics and function were assessed in 10 anesthetized newborn rabbits undergoing acute hyperoxemia for 1 h. The hyperoxemic period either followed (group 1: n = 5) or preceded (group 2: n = 5) a normoxemic control period. Renal blood flow (RBF) and glomerular filtration rate (GFR) were assessed by the clearance of p-aminohippuric acid and inulin, respectively. Urine flow rate, GFR, RBF, renal vascular resistance, filtration fraction and sodium fractional excretion remained unchanged throughout the study whatever the order of the normoxemic and hyperoxemic periods. It is concluded that hyperoxemia up to PaO2 of 170 mm Hg does not alter renal function.
对10只接受1小时急性高氧血症的麻醉新生兔的肾血流动力学和功能进行了评估。高氧血症期要么在正常氧合对照组之后（第1组：n = 5），要么在其之前（第2组：n = 5）。分别通过对氨基马尿酸和菊粉清除率评估肾血流量（RBF）和肾小球滤过率（GFR）。无论正常氧合期和高氧血症期的顺序如何，在整个研究过程中，尿流率、GFR、RBF、肾血管阻力、滤过分数和钠排泄分数均保持不变。得出的结论是，高达170 mmHg的PaO₂的高氧血症不会改变肾功能。
