Toniolo P G, Pasternack B S, Shore R E, Sonnenschein E, Koenig K L, Rosenberg C, Strax P, Strax S
Institute of Environmental Medicine, New York University Medical Center, NY 10010.
Breast Cancer Res Treat. 1991 May;18 Suppl 1:S23-6. doi: 10.1007/BF02633522.
A cohort study is under way in New York City to evaluate how levels of endogenous reproductive hormones influence the risk of breast cancer. The study, in which approximately 15,000 women are being recruited, utilizes a prospective design in which volunteers are asked to provide repeated specimens of serum during the period 1985-1992. A case-control study nested within the cohort is planned by which specimens from all cases arising in the population and from a randomly selected sample of time-matched controls will be analyzed and compared. As of December 31, 1989, 13,609 volunteers had donated blood specimens, about 50% of whom had already donated more than once. Of the 187 incident breast cancer cases who are expected to arise in the cohort before the end of 1992, 77 have been detected thus far.
纽约市正在进行一项队列研究，以评估内源性生殖激素水平如何影响患乳腺癌的风险。该研究正在招募约15000名女性，采用前瞻性设计，要求志愿者在1985年至1992年期间多次提供血清样本。计划在该队列中进行一项巢式病例对照研究，将分析和比较该人群中所有病例以及随机选择的时间匹配对照样本。截至1989年12月31日，13609名志愿者已捐献血液样本，其中约50%的人不止捐献过一次。预计在1992年底前该队列中会出现187例乳腺癌新发病例，到目前为止已检测出77例。
