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近期关于哌喹和羟基哌喹抗疟疗效的研究。

Recent studies on antimalarial efficacy of piperaquine and hydroxypiperaquine.

作者信息

Chen L

机构信息

Laboratory for Antimalarial Drug Research, Second Military Medical University, Shanghai.

出版信息

Chin Med J (Engl). 1991 Feb;104(2):161-3.

PMID:1874015
Abstract

Piperaquine and hydroxypiperaquine seem to be successful candidates of antimalarial drugs in China. Their antimalarial efficacy, experimental resistance, combination, mode of antimalarial action and clinical trials are described briefly.

摘要

在中国，哌喹和羟基哌喹似乎是成功的抗疟药物候选者。简要描述了它们的抗疟功效、实验性抗药性、联合用药、抗疟作用方式及临床试验情况。

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1
Recent studies on antimalarial efficacy of piperaquine and hydroxypiperaquine.近期关于哌喹和羟基哌喹抗疟疗效的研究。
Chin Med J (Engl). 1991 Feb;104(2):161-3.
2
In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models.合成过氧化物RBx11160（OZ277）与哌喹在疟原虫模型中的体外和体内相互作用
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[Studies on piperaquine as long-acting antimalarial drug against Plasmodium berghei in mice].[关于哌喹作为抗小鼠伯氏疟原虫长效抗疟药的研究]
Yao Xue Xue Bao. 1982 Dec;17(12):894-8.
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[Antimalarial activities of hydroxypiperaquine and its phosphate against Plasmodium berghei and Plasmodium cynomolgi].羟哌喹及其磷酸盐对伯氏疟原虫和食蟹猴疟原虫的抗疟活性
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Recent developments in naturally derived antimalarials: cryptolepine analogues.天然来源抗疟药的最新进展：隐丹参酮类似物
J Pharm Pharmacol. 2007 Jun;59(6):899-904. doi: 10.1211/jpp.59.6.0017.
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[Use of mefloquine as an antimalarial].[甲氟喹作为抗疟药的应用]
Bull World Health Organ. 1983;61(3):401-11.
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Antimalarial aminoalcohol alternatives to mefloquine.甲氟喹的抗疟氨基醇替代物。
Acta Trop. 1980 Sep;37(3):232-7.
8
[Resistance to piperaquine phosphate in Hainan islanders with pernicious malaria].
Zhonghua Yi Xue Za Zhi. 1985 Aug;65(8):483-4.
9
[In vivo sensitivity of Plasmodium falciparum to piperaquine phosphate assayed in Linshui and Baisha counties, Hainan Province].
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Chemotherapeutic studies with mefloquine and selection of a mefloquine resistant strain of Plasmodium berghei.用甲氟喹进行化疗研究及伯氏疟原虫耐甲氟喹株的选育。
Indian J Med Res. 1979 Dec;70 Suppl:95-102.

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Effects of a high-fat meal on the relative oral bioavailability of piperaquine.高脂餐对哌喹相对口服生物利用度的影响。
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Population pharmacokinetics of piperaquine in adults and children with uncomplicated falciparum or vivax malaria.磷酸哌喹在非复杂性恶性疟或间日疟成人及儿童中的群体药代动力学。
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