O'Byrne K T, Thalabard J C, Grosser P M, Wilson R C, Williams C L, Chen M D, Ladendorf D, Hotchkiss J, Knobil E
Laboratory for Neuroendocrinology, University of Texas Medical School, Houston 77225.
Endocrinology. 1991 Sep;129(3):1207-14. doi: 10.1210/endo-129-3-1207.
Continuous monitoring of the electrophysiological manifestations of GnRH pulse generator activity was achieved by radiotelemetry throughout the menstrual cycles of unrestrained rhesus monkeys. The characteristic increases in hypothalamic multiunit activity (MUA volleys) associated with each LH pulse measured in the peripheral circulation were of lower frequency during the luteal phase than in the follicular phase of the cycle. Multiunit activity volley frequency increased as functional luteolysis progressed and achieved maxima of approximately one volley per hour within the first few days of the follicular phase. Unexpectedly, a dramatic decline in pulse generator frequency was observed coincidentally with the initiation of the preovulatory LH surge. Evidence is presented to support the conclusion that this deceleration of pulse generator activity is the consequence of the preovulatory rise in plasma estrogen concentration. As reported in women, a significant reduction in GnRH pulse generator frequency was observed at night during the follicular phase, but not during the luteal phase, of the menstrual cycle.
通过无线电遥测技术，在未受束缚的恒河猴整个月经周期中，对促性腺激素释放激素（GnRH）脉冲发生器活动的电生理表现进行了连续监测。在黄体期，与外周循环中每次促黄体生成素（LH）脉冲相关的下丘脑多单位活动（MUA 群峰）的特征性增加频率低于卵泡期。随着功能性黄体溶解的进展，多单位活动群峰频率增加，并在卵泡期的头几天内达到每小时约一次群峰的最大值。出乎意料的是，在排卵前LH峰开始时，同时观察到脉冲发生器频率急剧下降。有证据支持这样的结论，即脉冲发生器活动的这种减速是血浆雌激素浓度排卵前升高的结果。正如在女性中所报道的那样，在月经周期的卵泡期夜间观察到GnRH脉冲发生器频率显著降低，但在黄体期则未观察到。
