Shimaji H, Shirahase H, Kanda M, Osumi S, Kurahashi K
Pharmacology Division, Kyoto University, Japan.
Eur J Pharmacol. 1991 Apr 17;196(2):197-9. doi: 10.1016/0014-2999(91)90428-s.
Modulation of the vasoinhibitory effect of NKY-722 by vascular endothelial cells was studied in canine mesenteric arteries. A high concentration of NKY-722 accumulated in the endothelium-intact arteries and its accumulation in endothelium-removed arteries was significantly less. The vasoinhibitory effect of NKY-722 in endothelium-intact arteries was significantly weaker than that in endothelium-removed arteries. These results suggest that endothelial cells can attenuate the vasoinhibitory effect of NKY-722.
在犬肠系膜动脉中研究了血管内皮细胞对NKY - 722血管抑制作用的调节。高浓度的NKY - 722在完整内皮的动脉中蓄积，而在去除内皮的动脉中的蓄积量显著减少。NKY - 722在完整内皮动脉中的血管抑制作用明显弱于去除内皮的动脉。这些结果表明，内皮细胞可减弱NKY - 722的血管抑制作用。
