内皮细胞可调节Ca2+通道拮抗剂NKY-722对犬肠系膜动脉的血管抑制作用。
Endothelial cells modulate the vasoinhibitory effect of NKY-722, a Ca2+ channel antagonist, in canine mesenteric arteries.
作者信息
Shimaji H, Shirahase H, Kanda M, Osumi S, Kurahashi K
机构信息
Pharmacology Division, Kyoto University, Japan.
出版信息
Eur J Pharmacol. 1991 Apr 17;196(2):197-9. doi: 10.1016/0014-2999(91)90428-s.
Modulation of the vasoinhibitory effect of NKY-722 by vascular endothelial cells was studied in canine mesenteric arteries. A high concentration of NKY-722 accumulated in the endothelium-intact arteries and its accumulation in endothelium-removed arteries was significantly less. The vasoinhibitory effect of NKY-722 in endothelium-intact arteries was significantly weaker than that in endothelium-removed arteries. These results suggest that endothelial cells can attenuate the vasoinhibitory effect of NKY-722.
在犬肠系膜动脉中研究了血管内皮细胞对NKY - 722血管抑制作用的调节。高浓度的NKY - 722在完整内皮的动脉中蓄积，而在去除内皮的动脉中的蓄积量显著减少。NKY - 722在完整内皮动脉中的血管抑制作用明显弱于去除内皮的动脉。这些结果表明，内皮细胞可减弱NKY - 722的血管抑制作用。
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