肾上腺素能激动剂和环磷酸腺苷对棕色脂肪组织钠钾ATP酶活性的影响。
The effect of adrenergic agonists and cyclic AMP on the Na+/K+ ATPase activity of brown adipose tissue.
作者信息
Horwitz B A, Eaton M
出版信息
Eur J Pharmacol. 1975 Nov;34(1):241-5. doi: 10.1016/0014-2999(75)90247-2.
PMID:187433
Abstract
The Na+/K+ ATPase activity of membrane fractions prepared from brown adipose tissue of cold-acclimated rats could be stimulated by addition of any one of the following: norepinephrine, isoproterenol, cyclic AMP or phenylephrine. These results are consistent with the proposal that in the intact brown adipocyte, the norepinephrine-induced stimulation of the Na+/K+ membrane pump is associated with alpha- as well as beta-adrenergic pathways and is, in part, mediated via cyclic AMP.
摘要
从冷适应大鼠的棕色脂肪组织制备的膜组分的钠钾ATP酶活性，可通过添加以下任何一种物质来刺激：去甲肾上腺素、异丙肾上腺素、环磷酸腺苷或去氧肾上腺素。这些结果与以下观点一致：在完整的棕色脂肪细胞中，去甲肾上腺素诱导的钠钾膜泵刺激与α和β肾上腺素能途径相关，并且部分是通过环磷酸腺苷介导的。
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