Ohno T, Sabra R, Branch R A
Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee 37232.
Hepatology. 1991 Sep;14(3):511-7.
Recently it was suggested that the onset of sodium retention in experimental cirrhosis in rats is related to a critical threshold of hepatic function, as assessed by the aminopyrine breath test. The aim of this study was to evaluate whether sodium retention occurred after two-thirds hepatectomy in rats and to investigate the relationship between sodium retention and changes in hepatic function associated with liver regeneration in this model. Sodium balance, creatinine clearance, serum sodium and the aminopyrine rate constant of elimination were evaluated daily for 4 days after surgery in partially hepatectomized (n = 6) and sham-operated rats (n = 6). All rats in the partial hepatectomy group exhibited sodium retention (sodium balance greater than 0.7 mmol/day) 24 hr after surgery. This was associated with a 62% reduction of the aminopyrine rate constant of elimination. Spontaneous natriuresis which occurred between 2 and 4 days after surgery, was associated with an increase in the aminopyrine rate constant of elimination (from 0.73 +/- 0.02 x 10(-2) min-1 on the last day of sodium retention to 0.95 +/- 0.04 x 10(-2) min-1 on the first day of natriuresis [p less than 0.05]). In contrast, no change in creatinine clearance occurred over the same period. A negative curvilinear association was found between sodium balance and the aminopyrine rate constant of elimination in all animals (r = -0.72, p less than 0.001). These observations indicate that natriuresis is related to the recovery of liver function, not to changes in creatinine clearance. In conclusion, the concept of a critical threshold of liver function below which sodium retention occurs has been substantiated in this model of hepatic dysfunction.
最近有人提出，大鼠实验性肝硬化中钠潴留的发生与通过氨基比林呼吸试验评估的肝功能临界阈值有关。本研究的目的是评估大鼠三分之二肝切除术后是否发生钠潴留，并研究该模型中钠潴留与肝再生相关的肝功能变化之间的关系。在部分肝切除的大鼠（n = 6）和假手术大鼠（n = 6）术后4天每天评估钠平衡、肌酐清除率、血清钠和氨基比林消除速率常数。部分肝切除组的所有大鼠在术后24小时均出现钠潴留（钠平衡大于0.7 mmol/天）。这与氨基比林消除速率常数降低62%有关。术后2至4天出现的自发性利钠与氨基比林消除速率常数增加有关（从钠潴留最后一天的0.73±0.02×10⁻² min⁻¹增加到利钠第一天的0.95±0.04×10⁻² min⁻¹ [p < 0.05]）。相比之下，同期肌酐清除率无变化。在所有动物中，钠平衡与氨基比林消除速率常数之间发现负曲线相关（r = -0.72，p < 0.001）。这些观察结果表明，利钠与肝功能恢复有关，而与肌酐清除率变化无关。总之，在这个肝功能障碍模型中，钠潴留发生的肝功能临界阈值概念得到了证实。
