Ray A, Mediratta P K, Puri S, Sen P
Department of Pharmacology, University College of Medical Sciences, Delhi, India.
Indian J Exp Biol. 1991 Mar;29(3):233-6.
Effects of restraint stress (24 hr at room temperature) were evaluated on some immunological, visceral and endocrinal responses in rats. In animals sensitized with sheep RBC (SRBC), restraint stress (a) prevented the booster-induced rise in anti-SRBC antibody titre, (b) induced gastric mucosal erosions, and (c) elevated plasma corticosterone, when compared to non-stressed controls. Diazepam (1 or 10 mg/kg) consistently attenuated the effects of stress on all three parameters studied. The opioid antagonist, naltrexone (1 or 5 mg/kg) tended to aggravate these stress-induced effects. These concurrent biological changes during stress and their modulation by drugs are discussed in light of a possible correlation between endocrinal, immunological and visceral changes during such aversive stimuli.
评估了束缚应激（室温下24小时）对大鼠一些免疫、内脏和内分泌反应的影响。在用绵羊红细胞（SRBC）致敏的动物中，与未应激的对照组相比，束缚应激（a）阻止了加强免疫诱导的抗SRBC抗体滴度升高，（b）导致胃黏膜糜烂，以及（c）使血浆皮质酮升高。地西泮（1或10 mg/kg）始终减弱应激对所研究的所有三个参数的影响。阿片类拮抗剂纳曲酮（1或5 mg/kg）倾向于加重这些应激诱导的效应。根据在这种厌恶刺激期间内分泌、免疫和内脏变化之间可能的相关性，讨论了应激期间这些同时发生的生物学变化及其药物调节作用。
