Brooks L W, Blais F X
Riverside Hospital, Trenton, Mich.
J Am Osteopath Assoc. 1991 Jun;91(6):601-5.
Coumarin skin necrosis is a rare and usually unpredictable complication of coumarin therapy, occasionally leading to death. Onset is usually between the third and sixth day of coumarin therapy. The patient most commonly complains of pain in a region of abundant subcutaneous fat, with progression to erythema, petechiae, and gangrenous necrosis. Thrombosis of the dermal and the subcutaneous veins is demonstrated pathologically. We describe a case and review the pathogenesis, treatment, and prevention of this lesion.
香豆素类药物所致皮肤坏死是香豆素类药物治疗中一种罕见且通常不可预测的并发症，偶尔会导致死亡。发病通常在香豆素类药物治疗的第3至6天之间。患者最常主诉皮下脂肪丰富区域疼痛，随后发展为红斑、瘀点和坏疽性坏死。病理检查显示真皮和皮下静脉血栓形成。我们报告1例病例，并对该病变的发病机制、治疗及预防进行综述。
