Austin S M, DiPietro J A, Foreman J H, Baker G J, Todd K S
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign 61801.
J Am Vet Med Assoc. 1991 Jun 1;198(11):1946-9.
Sixteen helminth-free pony foals were inoculated with a mean (+/- SD) 2,000 (+/- 545.5) infective Parascaris equorum eggs (day 0). Foals were allocated to replicates of 4, and treatments within each replicate were assigned at random. Treatment administered on postinoculation day (PID) 28 included no treatment (control), 0.2 mg of ivermectin/kg of body weight, 10 mg of oxibendazole/kg, or 6.6 mg of pyrantel base (pamoate)/kg. Paste formulations of the anthelmintics were administered orally. The foals were euthanatized 14 days after treatment (PID 42) and examined for P equorum larvae in the small intestine. The mean +/- SD (and range) numbers of fourth-stage P equorum larvae recovered from nontreated foals and those treated with ivermectin, pyrantel, or oxibendazole were 1,603.8 +/- 1,026.8 (305 to 2,480), 29.3 +/- 55.8 (0 to 113), 413.0 +/- 568.1 (0 to 1,204), or 889.5 +/- 1,123.1 (1 to 2,345), respectively. Compared with the value for control (nontreated) foals, treatment with ivermectin, pyrantel, and oxibendazole was 98.2, 74.2, and 44.5% effective, respectively, when administered 28 days after experimentally induced infection with P equorum. Adverse reactions attributable to treatment were not observed.
16匹未感染蠕虫的小马驹接种了平均（±标准差）2000（±545.5）个感染性马副蛔虫卵（第0天）。小马驹被分成每组4匹的重复组，每组内的处理随机分配。接种后第28天（PID 28）的处理包括不进行处理（对照）、0.2毫克伊维菌素/千克体重、10毫克奥苯达唑/千克或6.6毫克噻嘧啶碱基（双羟萘酸盐）/千克。驱虫药的糊剂制剂经口服给药。在处理后14天（PID 42）对小马驹实施安乐死，并检查小肠中的马副蛔虫幼虫。从未处理的小马驹以及用伊维菌素、噻嘧啶或奥苯达唑处理的小马驹中回收的第四期马副蛔虫幼虫的平均±标准差（及范围）数量分别为1603.8±1026.8（305至2480）、29.3±55.8（0至113）、413.0±568.1（0至1204）或889.5±1123.1（1至2345）。与对照（未处理）小马驹的值相比，在经实验诱导感染马副蛔虫28天后给予伊维菌素、噻嘧啶和奥苯达唑处理的有效性分别为98.2%、74.2%和44.5%。未观察到与处理相关的不良反应。
