DiPietro J A, Lock T F, Todd K S, Sanecki R K
Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana 61801.
Am J Vet Res. 1988 Nov;49(11):1983-5.
A controlled test was carried out on 15 pony foals inoculated with 1,500 +/- 108.8 infective Parascaris equorum eggs. The foals were assigned to 3 treatment groups. Treatments given on postinoculation day 11 included 0.2 mg of ivermectin/kg of body weight, formulated as paste (n = 5), or liquid (n = 5), or no treatment (controls; n = 5). The foals were euthanatized on postinoculation day 25, and examined for larvae in the small intestine, lungs, and liver. Larvae were not found in foals treated with ivermectin liquid or paste, whereas significantly (P less than 0.05) higher mean numbers (960.9; range, 379 to 1,736) of 4th-stage larvae were found in the controls. Histologic and gross examination of lungs and liver revealed pathologic changes attributable to P equorum migration that were similar in all foals. Adverse reactions to treatment were not observed.
对15匹接种1500±108.8个感染性马副蛔虫卵的小马驹进行了对照试验。这些马驹被分为3个治疗组。接种后第11天给予的治疗包括每千克体重0.2毫克伊维菌素，剂型为膏剂（n = 5）或液剂（n = 5），或不进行治疗（对照组；n = 5）。在接种后第25天对马驹实施安乐死，并检查小肠、肺和肝脏中的幼虫。在接受伊维菌素液剂或膏剂治疗的马驹中未发现幼虫，而在对照组中发现了数量显著更高（P < 0.05）的平均第四期幼虫（960.9；范围为379至1736）。对肺和肝脏的组织学和大体检查显示，所有马驹中均出现了归因于马副蛔虫移行的病理变化。未观察到治疗的不良反应。
