Funk Agnes P, George Mark S
Brain Stimulation Laboratory, Psychiatry Department, Medical University of South Carolina (MUSC), Charleston, South Carolina, USA.
Clin EEG Neurosci. 2008 Jul;39(3):125-30. doi: 10.1177/155005940803900306.
We review studies that have used EEG as a response biomarker in depression, and then present preliminary EEG change data from an ongoing TMS depression treatment trial. These data in 4 depressed subjects over 3 weeks of treatment suggest but do not prove that there may be asymmetry changes that occur both within a daily TMS session and over the course of several weeks that may be associated with antidepressant response. EEG shows potential as a biomarker of response for depression treatments, particularly the brain stimulation devices, which, unlike medications, can focally interact with neural tissue in specific frequency patterns.
我们回顾了将脑电图（EEG）用作抑郁症反应生物标志物的研究，然后展示了一项正在进行的经颅磁刺激（TMS）治疗抑郁症试验的初步脑电图变化数据。这4名抑郁症患者在3周治疗期间的数据表明，但并未证明，在每日的TMS治疗过程中以及数周的疗程中可能会出现不对称变化，这些变化可能与抗抑郁反应有关。脑电图显示出作为抑郁症治疗反应生物标志物的潜力，特别是对于脑刺激设备而言，与药物不同，脑刺激设备可以以特定频率模式与神经组织进行局部相互作用。
