[一组意大利深静脉血栓形成患者的血栓形成倾向危险因素评估]
[Thrombophilia risk factors evaluation in a group of Italian patients with deep venous thrombosis].
作者信息
Valverde Sara, Antico Francesco, Trabuio Ernesto, Basso Daniela, Navaglia Filippo, Orlandini Elisa, Giacomini Alda, Manoni Fabio, Gessoni Gianluca
机构信息
Servizio di Medicina di Laboratorio, Ospedale, Chioggia.
出版信息
Recenti Prog Med. 2008 Jul-Aug;99(7-8):348-53.
UNLABELLED
Venous thrombosis usually results from coexistence of multiple genetic and acquired risk factors with a trigger condition. In this study the authors report their experience in a cohort of Italian patients with previous venous thrombosis.
MATERIAL AND METHODS
We considered 292 consecutive patients. Each patient was studied by using a panel of functional and genetic tests to detect some of the most relevant thrombophilia risk factors.
RESULTS
The single most frequent thrombophilia risk factor was activated C protein resistance due to FV Leiden. Tests for anti phospholipids auto antibodies showed reactivity in 62 subjects.
CONCLUSION
The great majority (80%) of patients showed almost one thrombophilia risk factor. Presence of multiple risk factors was demonstrated in 128 (44%) patients.
未标注
静脉血栓形成通常是多种遗传和后天危险因素与触发条件共同存在导致的。在本研究中，作者报告了他们对一组既往有静脉血栓形成的意大利患者的研究经验。
材料与方法
我们纳入了292例连续的患者。对每位患者进行了一组功能和基因检测，以检测一些最相关的易栓症危险因素。
结果
最常见的单一易栓症危险因素是因因子V莱顿突变导致的活化蛋白C抵抗。抗磷脂自身抗体检测显示62名受试者呈阳性反应。
结论
绝大多数（80%）患者显示出几乎一种易栓症危险因素。128例（44%）患者存在多种危险因素。
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