Scolari Francesco, Turina Silvia, Venturelli Chiara, Dallera Nadia, Valerio Francesca, Mazzola Giuseppe, Faberi Elena, Sottini Laura, Kenou Rosyane
Divisione di Nefrologia, Presidio di Montichiari dell'Azienda Ospedaliera Spedali Riuniti di Brescia, Montichiari.
Recenti Prog Med. 2008 Jul-Aug;99(7-8):377-88.
Atheroembolic renal disease is a part of a multisystem disease and can be defined as renal failure secondary to the occlusion of renal arterioles and glomerular capillaries with cholesterol crystal emboli deriving from the aorta and other major arteries. The kidney is usually involved because of the proximity of the renal arteries to abdominal aorta (where the erosion of atheromatous plaque is most likely to occur), and the high renal blood flow. Cholesterol crystal embolism can also occur in other visceral organs, as well as in the upper and lower extremities. Embolization may occur spontaneously or after angiographic and surgical procedures, and anticoagulation. Atheroembolic renal disease is an important yet underdiagnosed component of the spectrum of kidney diseases associated with atherosclerosis and remains an unexplored field of nephrology research.
动脉粥样硬化栓塞性肾病是多系统疾病的一部分,可定义为继发于肾小动脉和肾小球毛细血管被来自主动脉和其他主要动脉的胆固醇结晶栓子阻塞后的肾衰竭。由于肾动脉靠近腹主动脉(动脉粥样硬化斑块最易发生糜烂的部位)以及肾血流量高,肾脏通常会受累。胆固醇结晶栓塞也可发生于其他内脏器官以及上下肢。栓塞可自发发生,也可在血管造影、外科手术及抗凝治疗后出现。动脉粥样硬化栓塞性肾病是与动脉粥样硬化相关的一系列肾脏疾病中一个重要但未被充分诊断的组成部分,仍是肾脏病学研究中一个未被探索的领域。