Strada Elena, Battistelli Luisita, Savazzi Giorgio
Dipartimento di Clinica Medica e Nefrologia, Università, Parma.
Recenti Prog Med. 2008 Jul-Aug;99(7-8):389-94.
Bence-Jones proteinuria consists in monoclonal light chains into the urine. Normally kidney eliminates light chains but, when light chains are in excess, they make histological and functional lesion to tubules, glomerulus and vessels both by direct action, or lysosomal enzyme releasing or making tubular obstruction. We analyse these kidney's damages from the morphological and functional point of view. Bence-Jones proteinuria can be detected by urinary protein electrophoresis, immunoelectrophoresis, immunofixation electrophoresis, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, two-dimensional electrophoresis and capillary electrophoresis.
本周氏蛋白尿是指单克隆轻链进入尿液。正常情况下，肾脏可清除轻链，但当轻链过量时，它们会通过直接作用、释放溶酶体酶或造成肾小管梗阻，对肾小管、肾小球和血管造成组织学和功能性损害。我们从形态学和功能学角度分析这些肾脏损害。可通过尿蛋白电泳、免疫电泳、免疫固定电泳、十二烷基硫酸钠-聚丙烯酰胺凝胶电泳、二维电泳和毛细管电泳检测本周氏蛋白尿。
