Chao N J, Nademanee A P, Long G D, Schmidt G M, Donlon T A, Parker P, Slovak M L, Nagasawa L S, Blume K G, Forman S J
Department of Medicine, Stanford University Medical Center, CA.
J Clin Oncol. 1991 Sep;9(9):1575-9. doi: 10.1200/JCO.1991.9.9.1575.
Alkylating agents used either with or without radiation therapy have been associated with the development of myelodysplastic syndrome (MDS) and acute nonlymphoblastic leukemia (ANLL) after treatment of both malignant and nonmalignant disorders. This report describes seven patients with recurrent Hodgkin's disease (HD) evaluated for bone marrow transplantation (BMT) who developed chromosomal abnormalities, and emphasizes the importance of bone marrow cytogenetic studies before bone marrow harvest. Three patients with histologically normal bone marrow underwent autologous BMT and subsequently developed an MDS or ANLL. Four patients had the clonal abnormality detected before bone marrow harvest and did not proceed to BMT.
无论是单独使用还是与放射治疗联合使用，烷化剂在治疗恶性和非恶性疾病后都与骨髓增生异常综合征（MDS）和急性非淋巴细胞白血病（ANLL）的发生有关。本报告描述了7例接受骨髓移植（BMT）评估的复发性霍奇金淋巴瘤（HD）患者，他们出现了染色体异常，并强调了在采集骨髓前进行骨髓细胞遗传学研究的重要性。3例骨髓组织学正常的患者接受了自体BMT，随后发展为MDS或ANLL。4例患者在采集骨髓前检测到克隆性异常，未进行BMT。
