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猕猴顶核动眼区的扫视爆发神经元。

Saccadic burst neurons in the oculomotor region of the fastigial nucleus of macaque monkeys.

作者信息

Ohtsuka K, Noda H

机构信息

Visual Science Department, School of Optometry, Indiana University, Bloomington 47405.

出版信息

J Neurophysiol. 1991 Jun;65(6):1422-34. doi: 10.1152/jn.1991.65.6.1422.

Abstract
  1. The discharge of 255 neurons in the fastigial nuclei of three trained macaque monkeys was investigated during visually guided saccades. Responses of these neurons were examined also during horizontal head rotation and during microstimulation of the oculomotor vermis (lobules VIc and VII). 2. One hundred and two units were characterized by bursts of firing in response to visually guided saccades. Ninety-eight of these (96.1%) were located within the anatomic confines of the fastigial oculomotor region (FOR), on the basis of reconstruction of recording sites. During contralateral saccades, these neurons showed bursts that preceded the onset of saccades (presaccadic burst), whereas, during ipsilateral saccades, they showed bursts associated with the end of saccades (late saccadic burst). They were hence named saccadic burst neurons. Sixty-one saccadic burst neurons (62.2%) were inhibited during microstimulation of the oculomotor vermis with currents less than 10 microA. 3. All saccadic burst neurons were spontaneously active, and the resting firing rate varied considerably among units, ranging from 10 to 50 imp/s. The tonic levels of activity did not correlate significantly with eye position. 4. The presaccadic burst started 18.5 +/- 4.7 (SD) ms (n = 45) before the onset of saccades in the optimal direction (the direction associated with the maximum values of burst lead time, number of spikes per burst, and burst duration). Optimal directions covered the entire contralateral hemifield, although there was a slightly higher incidence in both horizontal and upper-oblique directions in the present sample. The duration of the presaccadic burst was highly correlated with the duration of saccade (0.85 less than or equal to r less than or equal to 0.97). 5. The late saccadic burst was most robust in the direction opposite to the optimal in each unit (the nonoptimal direction). Its onset preceded the completion of ipsilateral saccade by 30.4 +/- 5.9 ms. The lead time to the end of saccade was consistent among different units and was constant also for saccades of various sizes. Thus the late saccadic burst started even before the saccade onset when the saccade duration was less than 30 ms. Unlike the presaccadic burst, its duration was not related to the duration of saccade. 6. Discharge rates of saccadic burst neurons were correlated neither to eye positions during fixation nor to the initial eye positions before saccades. 7. Eye-position units and horizontal head-velocity units were located rostral to the FOR.(ABSTRACT TRUNCATED AT 400 WORDS)
摘要
  1. 在三只经过训练的猕猴的顶核中,对255个神经元在视觉引导扫视过程中的放电情况进行了研究。在水平头部转动以及对动眼蚓部(小叶VIc和VII)进行微刺激时,也对这些神经元的反应进行了检查。2. 102个单位表现为在视觉引导扫视时出现放电爆发。根据记录位点的重建,其中98个(96.1%)位于动眼顶核区(FOR)的解剖范围内。在对侧扫视期间,这些神经元在扫视开始前出现爆发(扫视前爆发),而在同侧扫视期间,它们在扫视结束时出现爆发(扫视后期爆发)。因此,它们被命名为扫视爆发神经元。61个扫视爆发神经元(62.2%)在小于10微安电流刺激动眼蚓部时受到抑制。3. 所有扫视爆发神经元都有自发活动,静息放电率在各单位之间差异很大,范围为10至50次冲动/秒。活动的紧张性水平与眼位无显著相关性。4. 在最佳方向(与爆发提前时间、每次爆发的尖峰数量和爆发持续时间的最大值相关的方向)扫视开始前18.5±4.7(标准差)毫秒(n = 45),扫视前爆发开始。尽管在本样本中水平和上斜方向的发生率略高,但最佳方向覆盖了整个对侧半视野。扫视前爆发的持续时间与扫视持续时间高度相关(0.85≤r≤0.97)。5. 扫视后期爆发在每个单位的与最佳方向相反的方向(非最佳方向)最为强烈。它在同侧扫视完成前30.4±5.9毫秒开始。不同单位到扫视结束的提前时间一致,对于各种大小的扫视也恒定。因此,当扫视持续时间小于30毫秒时,扫视后期爆发甚至在扫视开始前就开始了。与扫视前爆发不同,其持续时间与扫视持续时间无关。6. 扫视爆发神经元的放电率与注视期间的眼位以及扫视前的初始眼位均无相关性。7. 眼位单位和水平头部速度单位位于FOR的前方。(摘要截于400字)

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