估算肾小球滤过率与甲状腺功能的关系：一项观察性研究。
The relationship between estimated glomerular filtration rate and thyroid function: an observational study.
作者信息
Woodward Anne, McCann Steven, Al-Jubouri Mohammad
机构信息
Department of Clinical Biochemistry, Whiston Hospital, Warrington Road, Merseyside, UK.
出版信息
Ann Clin Biochem. 2008 Sep;45(Pt 5):515-7. doi: 10.1258/acb.2008.007248.
BACKGROUND
Estimated glomerular filtration rate (eGFR) is now routinely reported by most National Health Service laboratories. There are many limitations when interpreting eGFR: thyroid dysfunction is not widely recognized as being one of these.
METHODS
We extracted from the pathology computer system results of all patients with hypothyroidism and hyperthyroidism who also had serum creatinine measured. We also extracted creatinine data on euthyroid patients. eGFR was calculated using the simplified Modification of Diet in Renal Disease Study equation.
RESULTS
The median eGFRs of the hypothyroid, euthyroid and hyperthyroid patients were 64, 77 and 107 mL/min/1.73 m(2), respectively; all groups were significantly different from each other (P < 0.001).
CONCLUSION
Thyroid dysfunction is associated with significant alterations in eGFR and actual GFR.
背景
目前大多数国民保健服务实验室都常规报告估算肾小球滤过率（eGFR）。在解读eGFR时存在许多局限性：甲状腺功能障碍未被广泛认为是其中之一。
方法
我们从病理计算机系统中提取了所有同时测定了血清肌酐的甲状腺功能减退和甲状腺功能亢进患者的结果。我们还提取了甲状腺功能正常患者的肌酐数据。使用简化的肾脏疾病饮食改良研究方程计算eGFR。
结果
甲状腺功能减退、甲状腺功能正常和甲状腺功能亢进患者的eGFR中位数分别为64、77和107 mL/（min/1.73 m²）；所有组之间均存在显著差异（P < 0.001）。
结论
甲状腺功能障碍与eGFR和实际肾小球滤过率的显著改变有关。
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