动物实验中，苄基四氢巴马汀对延迟后除极和触发活动以及希氏束电图和心电图的影响。
Effects of benzyltetrahydropalmatine on delayed after depolarization and triggered activity and on His-bundle electrogram and ECG in animal experiment.
作者信息
Yao W X, Jiang M X, Xia G J, Zeng W Z
机构信息
Department of Pharmacology, Tongji Medical University, Wuhan.
出版信息
J Tongji Med Univ. 1991;11(1):20-3. doi: 10.1007/BF02893182.
Standard microelectrode techniques were used to study the effects of benzyltetrahydropalmatine (BTHP) on ouabain-induced delayed after depolarization (DAD) and triggered activity in isolated guinea papillary muscles. The results indicate that ouabain-induced DAD and triggered activity were abolished by BTHP 100 mumol/L. In anesthetized rabbit ECG heart rate was reduced in a dose-dependent manner from control value of 288 +/- 14 to 261 +/- 14 (BTHP 5 mg/kg) and 226 +/- 36 bpm (BTHP 10 mg/kg). P-R interval was prolonged. In His-bundle electrogram, H-V interval and V duration were not affected, but A-H interval was prolonged from 41 +/- 3 to 45 +/- 5 ms.
采用标准微电极技术研究了苄基四氢巴马汀（BTHP）对哇巴因诱导的离体豚鼠乳头肌延迟后去极化（DAD）和触发活动的影响。结果表明，100 μmol/L的BTHP可消除哇巴因诱导的DAD和触发活动。在麻醉兔中，心电图心率以剂量依赖方式从对照值288±14降至261±14（BTHP 5 mg/kg）和226±36次/分钟（BTHP 10 mg/kg）。P-R间期延长。在希氏束电图中，H-V间期和V波时限未受影响，但A-H间期从41±3延长至45±5毫秒。
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