[苄基四氢巴马汀对延迟后去极化、触发活动及家兔希氏束电图的影响]
[Effects of benzyltetrahydropalmatine on delayed after depolarization and triggered activity and rabbit His-bundle electrogram].
作者信息
Yao W X, Xia G J, Zeng W Z, Jiang M X
机构信息
Department of Pharmacology, Tongji Medical University, Hankou, China.
出版信息
Zhongguo Yao Li Xue Bao. 1990 Mar;11(2):141-3.
Standard microelectrode techniques were used to study the effects of benzyltetrahydropalmatine (BTHP) on ouabain-induced delayed after depolarization (DAD) and triggered activity in isolated guinea pig papillary muscles. The results indicate that ouabain-induced DAD and triggered activity were abolished by BTHP 100 mumols/L. In anesthetized rabbit ECG heart rates were reduced in a dose-dependent manner from its control value of 288 +/- 14 to 261 +/- 14 (5 mg/kg) and 226 +/- 36 bpm (BTHP 10 mg/kg). P-R interval was prolonged. In His-bundle electrogram, H-V interval and V duration were not affected, but A-H interval was prolonged from 41 +/- 3 to 45 +/- 5 ms.
采用标准微电极技术研究了苄基四氢巴马汀（BTHP）对哇巴因诱导的豚鼠离体乳头肌延迟后去极化（DAD）和触发活动的影响。结果表明，100 μmol/L的BTHP可消除哇巴因诱导的DAD和触发活动。在麻醉兔中，心电图心率从其对照值288±14以剂量依赖方式降低至261±14（5 mg/kg）和226±36次/分钟（BTHP 10 mg/kg）。P-R间期延长。在希氏束电图中，H-V间期和V波时限未受影响，但A-H间期从41±3延长至45±5 ms。
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