Messerli F H, Kuchel O, Tolis G, Hamet P, Fraysse J, Genest J
Int J Clin Pharmacol Biopharm. 1976 Oct;14(3):189-94.
In healthy humans glucagon infusion resulted in a significant increase in blood sugar and in plasma cyclic AMP. No discernible hemodynamic effects were found. Isoproterenol infusion on a mole per mole basis in the same subjects induced a significant, although less pronounced rise in plasma cyclic AMP, heart rate, and a fall in diastolic blood pressure but had no effect on blood sugar. Propranolol administration abolished the hemodynamic effects of isoproterenol and significantly decreased the response of plasma cyclic AMP; the same blocking dosage had little effect on plasma cyclic AMP changes induced by glucagon wheras the response in blood sugar was significantly reduced. These data in vivo are compatible with the in vitro demonstration of separate receptors for glucagon and isoproterenol.
在健康人体中，输注胰高血糖素会导致血糖和血浆环磷酸腺苷（cAMP）显著升高。未发现明显的血流动力学效应。在相同受试者中，按每摩尔计算输注异丙肾上腺素会导致血浆cAMP显著升高（尽管升高程度较小）、心率加快以及舒张压下降，但对血糖无影响。给予普萘洛尔可消除异丙肾上腺素的血流动力学效应，并显著降低血浆cAMP的反应；相同的阻断剂量对胰高血糖素诱导的血浆cAMP变化影响不大，而对血糖反应则有显著降低。这些体内数据与体外证明的胰高血糖素和异丙肾上腺素的不同受体相符。
