Patrick Chaulk C, Kazandjian Vahé A, Vallejo Gutiérrez Paula
The Annie E. Casey Foundation, Baltimore, Maryland, USA.
Gac Sanit. 2008 Jul-Aug;22(4):362-70. doi: 10.1157/13125360.
Pulmonary tuberculosis rates are increasing worldwide, including in Spain. One of the main challenges when treating this disease is achieving treatment completion, since studies have shown that approximately 30-35% of all patients do not take their medications as intended. The present article explores a continuum of evaluation strategies and performance measures for assessing the effectiveness of community-based programs designed to enhance treatment completion in patients with active pulmonary tuberculosis. Four traditional evaluation strategies (case studies, retrospective and case-control studies, forecasting/modeling, and cost effectiveness analysis) and 2 emerging and promising approaches (quality of life assessment and indicators of the continuum of care) are presented. Several of the evaluation strategies reviewed indicate that treatment programs using directly observed therapy (DOT) that are comprehensive, community-based and patient-centered achieve the highest treatment completion rates. Combinations of these strategies are recommended to create a body of evidence capturing the impact and nuances of community-based public health interventions in improving health outcomes, in this case for patients with pulmonary tuberculosis.
全球包括西班牙在内,肺结核发病率都在上升。治疗这种疾病的主要挑战之一是实现治疗全程,因为研究表明,所有患者中约有30%至35%未按预期服药。本文探讨了一系列评估策略和绩效指标,用于评估旨在提高活动性肺结核患者治疗全程率的社区项目的有效性。文中介绍了四种传统评估策略(案例研究、回顾性研究与病例对照研究、预测/建模以及成本效益分析)以及两种新兴且有前景的方法(生活质量评估和连续医疗指标)。所审查的几种评估策略表明,采用直接观察治疗法(DOT)、全面、基于社区且以患者为中心的治疗项目能实现最高的治疗全程率。建议综合运用这些策略,以形成一系列证据,阐明基于社区的公共卫生干预措施在改善健康结果方面的影响及细微差别,在本案例中即针对肺结核患者。