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[杨桃(阳桃)中毒性脑病]

[Star fruit (Averrhoa carambola) toxic encephalopathy].

作者信息

Signaté A, Olindo S, Chausson N, Cassinoto C, Edimo Nana M, Saint Vil M, Cabre P, Smadja D

机构信息

Service de neurologie, centre hospitalo-universitaire, BP 632, 97200 Fort-de-France, Martinique.

出版信息

Rev Neurol (Paris). 2009 Mar;165(3):268-72. doi: 10.1016/j.neurol.2008.06.011. Epub 2008 Aug 27.

Abstract

Ingestion of star fruit (Averrhoa carambola) can induce severe intoxication in subjects with chronic renal failure. Oxalate plays a key role in the neurotoxicity of star fruit. We report the cases of two patients with unknown chronic renal insufficiency who developed severe encephalopathy after ingestion of star fruit. The two patients developed intractable hiccups, vomiting, impaired consciousness and status epilepticus. Diffusion-weighted MR imaging showed cortical and thalamic hyperintense lesions related to epileptic status. They improved after being submitted to continuous hemofiltration which constitutes the most effective treatment during the acute phase.

摘要

食用杨桃(阳桃)可使慢性肾衰竭患者发生严重中毒。草酸盐在杨桃的神经毒性中起关键作用。我们报告了两例慢性肾功能不全情况不明的患者,他们在食用杨桃后发生了严重脑病。这两名患者出现了顽固性呃逆、呕吐、意识障碍和癫痫持续状态。弥散加权磁共振成像显示与癫痫持续状态相关的皮质和丘脑高信号病变。在接受连续性血液滤过治疗后病情改善,连续性血液滤过是急性期最有效的治疗方法。

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