Sheldrick A J, Krug A, Markov V, Leube D, Michel T M, Zerres K, Eggermann T, Kircher T
Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, D-52074 Aachen, Germany.
Eur Psychiatry. 2008 Sep;23(6):385-9. doi: 10.1016/j.eurpsy.2008.05.002. Epub 2008 Aug 27.
The gene encoding catechol-O-methyltransferase (COMT), an enzyme which regulates prefrontal cortex dopamine, contains a common functional single nucleotide polymorphism (val158met, rs4680G/A), which accounts for part of the interindividual variance in performance during working memory tasks and also predicts personality traits. We examined the relationship between the val158met polymorphism and cognitive function as well as personality traits in 522 healthy individuals (mean age: 24.75 years, SD=5.84, mean years of education: 15.59, SD=2.65). COMT val158met genotype was related in allele dosage fashion to performance in an executive function test, with the met/met carriers scoring highest. Subjects carrying the met/met genotype also scored higher in the disorganization domain of the SPQ-B personality inventory. Consistent with evidence from previous studies, higher dopamine availability of the met/met genotype enhances prefrontally mediated executive function in healthy individuals. Furthermore, we replicated findings from a recent study whereby the COMT genotype also predicts disorganized personality features.
编码儿茶酚-O-甲基转移酶（COMT）的基因，该酶可调节前额叶皮质多巴胺，包含一种常见的功能性单核苷酸多态性（val158met，rs4680G/A），这解释了工作记忆任务期间个体表现差异的部分原因，并且还能预测人格特质。我们在522名健康个体（平均年龄：24.75岁，标准差=5.84，平均受教育年限：15.59，标准差=2.65）中研究了val158met多态性与认知功能以及人格特质之间的关系。COMT val158met基因型与执行功能测试中的表现呈等位基因剂量相关，其中met/met携带者得分最高。携带met/met基因型的受试者在SPQ-B人格量表的混乱维度上得分也更高。与先前研究的证据一致，met/met基因型更高的多巴胺可用性增强了健康个体前额叶介导的执行功能。此外，我们重复了最近一项研究的结果，即COMT基因型也能预测混乱的人格特征。
