Yazaki T, Iiyama T, Sato S, Hata R, Amemiya H, Tomomasa H, Muramatsu H, Iizumi T, Toyoshima A, Umeda T
Department of Urology, Teikyo University School of Medicine, Tokyo, Japan.
Nihon Jinzo Gakkai Shi. 1991 Apr;33(4):409-15.
Reports on renal cell carcinoma (RCC) as an incidental finding have been increasing in recent years as the imaging modalities including ultrasonography (US) and computerized tomography (CT) scan have gained popularity in clinical medicine. Because effective treatment in RCC is only surgical removal of the involved kidney even at present, it is imperative for urologists to find and to diagnose the RCC in early stage. Whether RCC found incidentally is in early stage cancer is not determined at present. To determine if the RCC found incidentally is in early stage cancer and if the survival rate is better than that of the RCC found with symptoms, we undertook the following study. Between December 1972 and March 1990, 65 patients with RCC were registered at the Department of Urology, Teikyo University Hospital. Of 65 patients 20 with RCC as an incidental finding were subjected to this study. 34 patients with RCC found with symptoms including hematuria were subjected to control group. Causes of the diagnosis in 20 patients included workup for non-urological diseases in 11 patients (55.0%), workup for urological disease other than RCC in 5 patients (25.0%) and routine medical checkup in 4 patients (20.0%). First-line imaging modalities for the diagnosis was US in 9 patients (45.0%), DIP in 6 patients (30.0%) and CT in 5 patients (25.0%). Size of the tumor, pathological stage (pT) and grade in these 20 patients were tended to be smaller and lower, respectively, but these results were not significant as compared to those of the control group. Incidence of the remote metastasis, at the time of diagnosis, however, was significantly lesser than that of the control group (p = 0.04).(ABSTRACT TRUNCATED AT 250 WORDS)
近年来,随着超声(US)和计算机断层扫描(CT)等成像方式在临床医学中越来越普及,关于肾细胞癌(RCC)作为偶然发现的报告不断增加。由于即使在目前,RCC的有效治疗方法也仅是手术切除患肾,因此泌尿外科医生必须尽早发现并诊断RCC。目前尚无法确定偶然发现的RCC是否处于癌症早期。为了确定偶然发现的RCC是否处于癌症早期以及其生存率是否高于有症状发现的RCC,我们进行了以下研究。1972年12月至1990年3月期间,东京医科大学医院泌尿外科登记了65例RCC患者。其中20例偶然发现的RCC患者纳入本研究。34例有血尿等症状发现的RCC患者作为对照组。20例患者的诊断原因包括:11例(55.0%)因非泌尿系统疾病检查,5例(25.0%)因RCC以外的泌尿系统疾病检查,4例(20.0%)因常规体检。诊断的一线成像方式中,9例(四十五点零%)为US,6例(30.0%)为静脉肾盂造影(DIP),5例(25.0%)为CT。这20例患者的肿瘤大小、病理分期(pT)和分级往往分别较小和较低,但与对照组相比,这些结果无显著差异。然而,诊断时远处转移的发生率明显低于对照组(p = 0.04)。(摘要截断于250字)