Kataoka K, Umekawa T, Katayama Y, Ishikawa Y, Kodama M, Takamura C, Takada M, Kato Y, Hohri K, Iguchi M
Department of Urology, Kinki University School of Medicine, Osaka, Japan.
Nihon Hinyokika Gakkai Zasshi. 1991 May;82(5):799-803. doi: 10.5980/jpnjurol1989.82.799.
Because human urine contains various substances which can affect each other, it is quite difficult to clarify the mechanism of formation of calcium oxalate (CaOx) crystal in urine. The authors recently determined CaOx crystalline content and the concentrations of other substances in urine specimens from patients with urolithiasis and healthy volunteers, and subjected the data to multi-regressive analysis for the purpose of assessing the effect of these urinary substances on CaOx crystal formation. 1. In analysis of urine from patients with urolithiasis, the partial correlation coefficients of CaOx crystal formation with oxalic acid, sodium, calcium, uric acid magnesium were 0.67, 0.28, 0.18, and -0.10, respectively. The formula of regression was as follows: Amount of CaOx crystal (X 10(6) microns3/ml) = 3.59 X 10(-2) Ox (mM/L) + 4.72 X 10(-3) Ca (mM/L) + 4.52 X 10(-3) Na (mM/L) + 2.51 X 10(-4) UA (mM/L) -2.39 X 10(-2) Mg (mM/L) -1.65. The multiple correlation coefficient was 0.759. Thus, in patients with urolithiasis, urinary crystal formation was most dependent on the oxalic acid level, sodium, calcium, and uric acid were found to promote crystal formation, while magnesium to suppress it. 2. In analysis of urine from healthy volunteers, the partial correlation coefficients of CaOx crystal formation with oxalic acid and inorganic phosphorus were 0.51 and -0.24, respectively. The formula of regression was as follows: Amount of CaOx crystal (X 10(6) microns3/ml) = 1.91 X 10(-2) Ox (mM/L) -3.43 X 10(-4) P (mM/L) +0.29 The multiple correlation coefficient was 0.525.(ABSTRACT TRUNCATED AT 250 WORDS)
由于人类尿液中含有多种会相互影响的物质，因此很难阐明草酸钙（CaOx）晶体在尿液中的形成机制。作者最近测定了尿路结石患者和健康志愿者尿液标本中CaOx晶体含量及其他物质的浓度，并对数据进行多元回归分析，以评估这些尿液物质对CaOx晶体形成的影响。1. 在尿路结石患者尿液分析中，CaOx晶体形成与草酸、钠、钙、尿酸镁的偏相关系数分别为0.67、0.28、0.18和 -0.10。回归公式如下：CaOx晶体量（×10⁶立方微米/毫升）= 3.59×10⁻²草酸（毫摩尔/升）+ 4.72×10⁻³钙（毫摩尔/升）+ 4.52×10⁻³钠（毫摩尔/升）+ 2.51×10⁻⁴尿酸（毫摩尔/升） - 2.39×10⁻²镁（毫摩尔/升） - 1.65。复相关系数为0.759。因此，在尿路结石患者中，尿晶体形成最依赖于草酸水平，钠、钙和尿酸促进晶体形成，而镁抑制晶体形成。2. 在健康志愿者尿液分析中，CaOx晶体形成与草酸和无机磷的偏相关系数分别为0.51和 -0.24。回归公式如下：CaOx晶体量（×10⁶立方微米/毫升）= 1.91×10⁻²草酸（毫摩尔/升） - 3.43×10⁻⁴磷（毫摩尔/升）+ 0.29。复相关系数为0.525。（摘要截选至250字）
