代谢综合征的诊断能否预测以低踝臂指数定义的外周动脉疾病的发生可能性？

Does diagnosis of metabolic syndrome predict the likelihood of peripheral arterial disease as defined by a low ankle-brachial index?

作者信息

López-Suárez Alejandro, Beltrán-Robles Manuel, Elvira-González Javier, Alwakil Michael, Bascuñana-Quirell Antonio, Rosal-Obrador Joan, Badani-Gutiérrez Hugo, Oliver-Pece Miguel, Pons-Raga Amparo, Ruiz-DeCastroviejo Juan, Cañas-Hormigo Francisco, Benítez-Rodríguez Encarnación

机构信息

Internal Medicine Department, Virgen del Camino Hospital, Sanlúcar de Barrameda Cádiz, Spain.

出版信息

Eur J Cardiovasc Prev Rehabil. 2008 Dec;15(6):693-7. doi: 10.1097/HJR.0b013e32830c1cc5.

DOI:10.1097/HJR.0b013e32830c1cc5

PMID:18756176

Abstract

BACKGROUND

There is limited information about whether a diagnosis of metabolic syndrome (MS) predicts peripheral arterial disease independently of diabetes. This study assessed whether MS adds prognostic information beyond that relating to diabetes in the identification of a low ankle-brachial index (ABI).

DESIGN

Cross-sectional population-based study of people aged 50-75 years.

METHODS

Eight hundred and fifty-eight participants were randomly selected. The likelihood of low ABI (<0.90) was calculated according to MS status before and after excluding diabetes. The National Cholesterol Education Panel and the International Diabetes Federation (IDF) definitions of MS were used.

RESULTS

The prevalence of National Cholesterol Education Panel-defined and IDF-defined MS, and low ABI was 57.8, 61.1 and 7.5%, respectively. When there were participants with three or more criteria for MS, participants with only three criteria, and participants with four or five criteria were compared with participants without MS, the odds ratio for low ABI was 1.89 (95% confidence interval, 1.08-3.30), 1.34 (0.70-2.60) and 2.70 (1.45-5.03), respectively. The association of MS and low ABI lost statistical significance after excluding diabetes. No difference was observed using the IDF definition of MS.

CONCLUSION

Screening of participants with MS does not improve the identification of abnormal ABI provided by diabetes.

摘要

背景

关于代谢综合征（MS）的诊断能否独立于糖尿病预测外周动脉疾病的信息有限。本研究评估了在识别低踝臂指数（ABI）方面，MS是否能提供超出糖尿病相关信息的预后信息。

设计

基于人群的横断面研究，研究对象为50 - 75岁人群。

方法

随机选取858名参与者。在排除糖尿病前后，根据MS状态计算低ABI（<0.90）的可能性。采用美国国家胆固醇教育计划和国际糖尿病联盟（IDF）对MS的定义。

结果

美国国家胆固醇教育计划定义的MS、IDF定义的MS以及低ABI的患病率分别为57.8%、61.1%和7.5%。当比较符合三条或更多MS标准的参与者、仅符合三条标准的参与者以及符合四条或五条标准的参与者与无MS的参与者时，低ABI的比值比分别为1.89（95%置信区间，1.08 - 3.30）、1.34（0.70 - 2.60）和2.70（1.45 - 5.03）。排除糖尿病后，MS与低ABI之间的关联失去统计学意义。使用IDF对MS的定义未观察到差异。