Alper Seth L
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Kidney Int. 2008 Sep;74(6):699-702. doi: 10.1038/ki.2008.357.
In the years since identification of autosomal-dominant polycystic kidney disease (ADPKD) genes, the lag time between initial understanding and translation to therapy has decreased rapidly. Albaqumi and colleagues describe a promising approach to slow ADPKD cyst enlargement through inhibition of the basolateral KCa3.1 K(+) channel, using a nontoxic small molecule with a close congener poised for rapid entry into the clinic. Cyst fluid accumulation can be blocked from both sides now.
自从鉴定出常染色体显性多囊肾病（ADPKD）基因以来的数年里，从最初了解到转化为治疗的时间间隔迅速缩短。阿尔巴库米及其同事描述了一种有前景的方法，即通过抑制基底外侧的KCa3.1钾通道来减缓ADPKD囊肿的增大，他们使用一种无毒的小分子，其结构类似物已准备好迅速进入临床应用。现在囊肿液的积聚可以从两方面得到阻断。
