Laín A, García-Casillas M A, Matute J A, Cañizo A, Parente A, Fanjul M, Carrera N, Vázquez J
Unidad de Cirugía Torácica y Vía Aérea, Servicio de Cirugía Pediátrica, Hospital Gregorio Marañón, Madrid.
Cir Pediatr. 2008 Jul;21(3):138-42.
Tracheal stenosis (TS) is an unusual and sometimes lethal condition. It's treatment is basically surgical and different techniques have been proposed.
Analyze the outcome of patients with TS diagnosed and treated in our institution realted to the applied surgical technique during the study period.
The clinical records of patients with TS (period 1991 to 2006) were reviewed analyzing the following variables: age, gender, associated malformations, intubation time, medium hospital stay and outcome. Patients were divided in 4 groups: conservative and endoscopic management (2 conservative, 1 dilatation, 1 laser), tracheal resection with termino-terminal anastomosis (RTA) (9 patients), tracheoplasties (slide or modified plasties) (20 patients) and anterior tracheoplasty with costal cartilage graft (TAIC) (6 patients). Results are expressed as media +/- standard error, comparative analysis was done using Chi square with continuity correction. Differences were considered statistically significant with a p < 0.05.
39 patients were reviewed (23 male, 16 female), medium age was 2.23 years. Associated malformations were: 12 vascular rings, 7 cardiac malformations, 4 Down syndromes, 1 pulmonary agenesia, 2 hemivertebtebrae, 1 renal agenesia and 1 cervicothoracic angiomatosis. Nineteen patients had short segment stenosis, 15 long segment stenosis (more than 1/3 of tracheal length) and 5 patients presented associated bronchial stenosis (most frequently right main bronchus). All TAIC failed: 4 deaths, 1 reestenosis and 1 persistent stenosis. In the tracheoplasty-group there were 2 exitus (1 due to a neurological lesion after a prolonged preoperative cardiorrespiratory arrest, one due to a surgical treatment delay with previous inadequate management). Patients treated with tracheoplasties and RTA had a favourable evolution and are asymptomatic in more than 80% of the cases after a mean follow-up of 59.9 +/- 7.4 months. In the conservative management group 2 patients died and 2 had a uneventful outcome. Global mortality was 20.5% (8 deaths). Differences observed in the mortality percentage between the study groups were statistically significant. (p = 0.0034) (50% in conservative management, 0% in RTA, 10% in tracheoplasties, 66.67% in TAIC). No statistically significant differences were found in the medium intubation time, medium hospital stay and medium follow-up time.
The fundamental treatment of the tracheal stenosis is the surgical approach. Patients should be studied with great detail taking into account associated malformations (mostly heart defects and vascular rings) and should be treated by a multidisciplinary group. Short segmental TS should be corrected with RTA, long TS with tracheoplasties (slide), remaining the TAIC technique obsolete.
气管狭窄(TS)是一种罕见且有时致命的疾病。其治疗基本为手术治疗,并且已经提出了不同的技术。
分析在我们机构诊断和治疗的气管狭窄患者的治疗结果,这些结果与研究期间应用的手术技术相关。
回顾了气管狭窄患者(1991年至2006年期间)的临床记录,分析以下变量:年龄、性别、相关畸形、插管时间、平均住院时间和治疗结果。患者分为4组:保守和内镜治疗(2例保守治疗、1例扩张治疗、1例激光治疗)、端端吻合气管切除术(RTA)(9例患者)、气管成形术(滑动或改良成形术)(20例患者)和带肋软骨移植的前路气管成形术(TAIC)(6例患者)。结果以平均值±标准误差表示,采用连续性校正的卡方检验进行比较分析。当p<0.05时,差异被认为具有统计学意义。
共回顾了39例患者(23例男性,16例女性),平均年龄为2.23岁。相关畸形包括:12例血管环、7例心脏畸形、4例唐氏综合征、1例肺不发育、2例半椎体、1例肾不发育和1例颈胸段血管瘤。19例患者为短节段狭窄,15例为长节段狭窄(超过气管长度的1/3),5例患者伴有支气管狭窄(最常见于右主支气管)。所有TAIC治疗均失败:4例死亡,1例再狭窄,1例持续性狭窄。在气管成形术组中有2例死亡(1例因术前长时间心肺骤停后神经损伤,1例因先前处理不当导致手术治疗延迟)。接受气管成形术和RTA治疗的患者病情进展良好,平均随访59.9±7.4个月后,超过80%的病例无症状。在保守治疗组中,2例患者死亡,2例预后良好。总死亡率为20.5%(8例死亡)。研究组之间观察到的死亡率差异具有统计学意义(p = 0.0034)(保守治疗组为50%,RTA组为0%,气管成形术组为10%,TAIC组为66.67%)。在平均插管时间、平均住院时间和平均随访时间方面未发现统计学显著差异。
气管狭窄的基本治疗方法是手术治疗。应详细研究患者,考虑相关畸形(主要是心脏缺陷和血管环),并应由多学科团队进行治疗。短节段气管狭窄应采用RTA矫正,长节段气管狭窄应采用气管成形术(滑动式),而TAIC技术已过时。