Cardoso Wellington V, Whitsett Jeffrey A
Pulmonary Center, Boston University School of Medicine, 715 Albany Street R-304, Boston, MA 02118, USA.
Proc Am Thorac Soc. 2008 Sep 15;5(7):767-71. doi: 10.1513/pats.200803-026HR.
In a recent workshop organized by the NIH-NHLBI, investigators working on different aspects of lung biology met to discuss recent progress regarding the origin, development, and characterization of the various cell lineages present in the lung in both normal and disease states. The workshop was entitled "Resident Cellular Components of the Human Lung: Current Knowledge and Goals for Research on Cell Phenotyping and Function." In this article we will highlight some of the developmental aspects of the lung discussed at the meeting. We will review information about developmental signals that are possibly reactivated during lung regeneration/repair and disease processes, and we will pose the questions and challenges viewed to be relevant to further advance the field.
在美国国立卫生研究院-国家心肺血液研究所（NIH-NHLBI）最近组织的一次研讨会上，致力于肺生物学不同方面研究的调查人员齐聚一堂，讨论了正常和疾病状态下肺中存在的各种细胞谱系的起源、发育和特征方面的最新进展。该研讨会的主题是“人类肺的驻留细胞成分：细胞表型分析和功能研究的当前知识与目标”。在本文中，我们将重点介绍会议上讨论的肺发育的一些方面。我们将回顾有关在肺再生/修复和疾病过程中可能重新激活的发育信号的信息，并提出我们认为与该领域进一步发展相关的问题和挑战。
