Wnt 信号在肺发育、再生和疾病进展中的作用。
Wnt signaling in lung development, regeneration, and disease progression.
机构信息
UCLA Department of Molecular Biology Interdepartmental Program, UCLA, Los Angeles, CA, USA.
UCLA Medical Scientist Training Program, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
出版信息
Commun Biol. 2021 May 20;4(1):601. doi: 10.1038/s42003-021-02118-w.
The respiratory tract is a vital, intricate system for several important biological processes including mucociliary clearance, airway conductance, and gas exchange. The Wnt signaling pathway plays several crucial and indispensable roles across lung biology in multiple contexts. This review highlights the progress made in characterizing the role of Wnt signaling across several disciplines in lung biology, including development, homeostasis, regeneration following injury, in vitro directed differentiation efforts, and disease progression. We further note uncharted directions in the field that may illuminate important biology. The discoveries made collectively advance our understanding of Wnt signaling in lung biology and have the potential to inform therapeutic advancements for lung diseases.
呼吸道是一个重要而复杂的系统，参与多种重要的生物学过程，包括黏液纤毛清除、气道传导和气体交换。Wnt 信号通路在多种情况下的肺生物学中发挥着几个关键且不可或缺的作用。本综述重点介绍了在肺生物学的多个领域中，包括发育、稳态、损伤后再生、体外定向分化努力以及疾病进展，描述 Wnt 信号在阐明生物学方面的重要作用的研究进展。我们进一步注意到该领域中尚未探索的方向，这些方向可能会揭示重要的生物学机制。这些发现共同推进了我们对肺生物学中 Wnt 信号的理解，并有可能为肺部疾病的治疗进展提供信息。
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