Hampel G, Reinke M, Hren J
Department of Clinical Pathology, University of Erlangen-Nürnberg, FRG.
Life Sci. 1991;49(12):881-8. doi: 10.1016/0024-3205(91)90173-9.
Antioxidants play an important role in the regulation of phospholipid hydrolysis and arachidonate metabolism. Supplementation of cultured human mesangial cells with selenium resulted in suppression of phospholipase A2-activity and significantly increased production of three major prostaglandins. However, prostacyclin synthesis benefits most from selenium supplementation, suggesting that there is a specific action of selenium-dependent glutathione peroxidase on this pathway. Like in endothelial cells, production of platelet activating factor is significantly inhibited by selenium supplementation.
抗氧化剂在磷脂水解和花生四烯酸代谢的调节中起重要作用。用硒补充培养的人系膜细胞可抑制磷脂酶A2活性，并显著增加三种主要前列腺素的产生。然而，前列环素的合成从硒补充中受益最大，这表明硒依赖性谷胱甘肽过氧化物酶对该途径有特定作用。与内皮细胞一样，补充硒可显著抑制血小板活化因子的产生。
