Tálosi Gyula, Boda Domokos
Department of Pediatrics, Albert Szent-Gyorgyi Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary.
Med Sci Monit. 2008 Sep;14(9):PI32-7.
Gastric tonometry was developed for measuring the partial pressure of carbon dioxide in the gastrointestinal tract and particularly for monitoring the clinical condition of patients in critical states. The ballooned catheter used in this technique has proved to be a reliable tool in adult patients, but its use in pediatrics is limited because of technical difficulties. The aims of this paper are to describe the technique of application of a recently developed gastric tonometric probe especially suitable for performing measurements on neonates and infants and to present the first human results.
MATERIAL/METHODS: Thirty-two neonates and infants requiring intensive care were monitored (age: 2-456 days, weight: 1200-6700 g), of whom 10 died. The pediatric index of mortality, acid-base parameters, PCO2 gap values, and intramucosal pH and pH gap values were measured or calculated. The new gastric tonometric probe, made of silicone rubber tubes, is balloon free. It is introduced into the stomach orally or nasopharyngeally through the use of a guide wire. After equilibration, the PCO2 level of the air inside the probe is measured with a capnograph.
Application of the new probe proved simple. The pediatric index of mortality scores (35.1%+/-19.6% vs. 14.6%+/-14.8%), PCO2 gap values (13.48+/-9.30 mmHg vs. 8.43+/-6.54 mmHg), and the systemic-intramucosal pH differences (0.124+/-0.074 vs. 0.079+/-0.054) were significantly higher in the non-surviving patients.
The new probe is well applicable for measurements of gastric PCO2 levels in infants.
胃张力测定法用于测量胃肠道内二氧化碳的分压,尤其用于监测危重症患者的临床状况。该技术中使用的带气囊导管在成年患者中已被证明是一种可靠的工具,但由于技术困难,其在儿科中的应用受到限制。本文的目的是描述一种最近开发的特别适用于新生儿和婴儿测量的胃张力测定探头的应用技术,并展示首批人体研究结果。
材料/方法:对32名需要重症监护的新生儿和婴儿进行了监测(年龄:2 - 456天,体重:1200 - 6700克),其中10名死亡。测量或计算了儿科死亡率指数、酸碱参数、PCO2差值、黏膜内pH值和pH差值。新型胃张力测定探头由硅橡胶管制成,无气囊。通过使用导丝经口或经鼻咽部将其插入胃内。平衡后,用二氧化碳监测仪测量探头内空气的PCO2水平。
新型探头的应用证明很简单。未存活患者的儿科死亡率指数评分(35.1%±19.6%对14.6%±14.8%)、PCO2差值(13.48±9.30 mmHg对8.43±6.54 mmHg)以及全身 - 黏膜内pH差值(0.124±0.074对0.079±0.054)显著更高。
新型探头非常适用于测量婴儿胃内的PCO2水平。