Sun Jielin, Zheng Siqun Lilly, Wiklund Fredrik, Isaacs Sarah D, Purcell Lina D, Gao Zhengrong, Hsu Fang-Chi, Kim Seong-Tae, Liu Wennuan, Zhu Yi, Stattin Pär, Adami Hans-Olov, Wiley Kathleen E, Dimitrov Latchezar, Sun Jishan, Li Tao, Turner Aubrey R, Adams Tamara S, Adolfsson Jan, Johansson Jan-Erik, Lowey James, Trock Bruce J, Partin Alan W, Walsh Patrick C, Trent Jeffrey M, Duggan David, Carpten John, Chang Bao-Li, Grönberg Henrik, Isaacs William B, Xu Jianfeng
Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
Nat Genet. 2008 Oct;40(10):1153-5. doi: 10.1038/ng.214. Epub 2008 Aug 31.
We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, approximately 26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 x 10(-9) for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.
我们在两个研究群体中对位于17q12的HNF1B基因进行了精细定位研究,并确定了与前列腺癌风险相关的第二个位点,该位点在第一个已知位点(rs4430796)着丝粒方向约26 kb处;这些位点被一个重组热点隔开。我们在另外五个群体中证实了第二个位点中的一个单核苷酸多态性(SNP,rs11649743)与前列腺癌的关联,七项研究联合进行等位基因检验的P值为1.7×10⁻⁹ 。对另一个SNP进行校正后,每个SNP的关联仍然显著。