Departamento de Urología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Marcoleta 352, Santiago, Chile,
J Cancer Res Clin Oncol. 2014 May;140(5):783-8. doi: 10.1007/s00432-014-1635-1. Epub 2014 Mar 14.
To study the association between the polymorphisms, rs1859962 and rs4430796, from the chromosomes 17q24 and 17q12, respectively, with the risk of prostate cancer (PCa) and its clinical characteristics in a Hispanic (Chilean) population.
This study included 33 controls and 167 patients diagnosed with PCa. The polymorphisms, rs1859962 and rs4430796, were analyzed on blood specimens using quantitative PCR. The genetic analysis of the qPCR data was performed using the SNPStats program. A comparison between the clinical characteristics of the prostate cancers from the patients and the presence of the different polymorphism genotypes detected in blood specimens obtained from these patients was performed using the IBM SPSS v20.0 software.
We observed no association of the SNPs and the risk of developing PCa (OR 0.84, 95 % CI 0.30-2.38, p = 1.0 to rs1859962 and OR 1.94, 95 % CI 0.57-6.52, p = 0.28 to rs4430796), both sporadic and hereditary. However, patients carrying the genotype G/G from the polymorphism rs4430796 had significantly higher PSA levels than patients carrying the other genotypes (15.05 ng/ml to G/G, 10 and 8.11 ng/ml to genotypes A/G y A/A, respectively, p = 0.01). Furthermore, patients with the genotype G/G of rs4430796 had higher tumor volume than other genotypes (9.45 cc to G/G and 5.22 cc to A/G + A/A, p = 0.04).
The polymorphism rs4430796 of the chromosome 17q12 appears to be a biomarker for cancer aggressiveness, increased PSA and tumor volume of PCa.
研究染色体 17q24 和 17q12 上的 rs1859962 和 rs4430796 多态性与前列腺癌（PCa）风险及其在西班牙裔（智利）人群中的临床特征的关联。
本研究纳入了 33 名对照者和 167 名确诊为 PCa 的患者。采用定量 PCR 分析血样中的 rs1859962 和 rs4430796 多态性。使用 SNPStats 程序对 qPCR 数据进行遗传分析。使用 IBM SPSS v20.0 软件比较患者前列腺癌的临床特征与从这些患者获得的血液样本中检测到的不同多态性基因型的存在。
我们没有观察到 SNP 与 PCa 发病风险相关（OR 0.84，95%CI 0.30-2.38，p=1.0 对 rs1859962 和 OR 1.94，95%CI 0.57-6.52，p=0.28 对 rs4430796），无论是散发性还是遗传性。然而，携带 rs4430796 多态性基因型 G/G 的患者 PSA 水平明显高于携带其他基因型的患者（G/G 为 15.05ng/ml，A/G 和 A/A 分别为 10 和 8.11ng/ml，p=0.01）。此外，携带 rs4430796 基因型 G/G 的患者肿瘤体积大于其他基因型（G/G 为 9.45cc，A/G+A/A 为 5.22cc，p=0.04）。
染色体 17q12 上的 rs4430796 多态性似乎是 PCa 侵袭性、PSA 升高和肿瘤体积增大的生物标志物。
