Frame Margaret, Norman Jim
Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR.
Nat Cell Biol. 2008 Sep;10(9):1017-9. doi: 10.1038/ncb0908-1017.
Talin can activate integrins to bind the extracellular matrix and also connect matrix-engaged integrins to the actin cytoskeleton. New work shows that cell spreading can be dissected into three distinct phases according to their differential requirements for talin function.
踝蛋白可激活整合素以结合细胞外基质,还能将与基质结合的整合素连接到肌动蛋白细胞骨架上。新的研究表明,根据细胞铺展对踝蛋白功能的不同需求,可将其分为三个不同阶段。