Arioz Dagistan Tolga, Saglam Hayrettin, Demirel Reha, Koken Gulengul, Cosar Emine, Sahin Figen Kir, Dursun Huseyin, Aral Ilknur, Onrat Ersel, Yilmazer Mehmet
Faculty of Medicine, Department of Obstetrics and Gynecology, Afyonkarahisar Kocatepe University, Afyonkarahisar, Turkey.
Adv Ther. 2008 Sep;25(9):925-34. doi: 10.1007/s12325-008-0090-2.
The aim of this study was to investigate the clinical relevance of dipper status in women with preeclampsia by comparing arterial stiffness index (SI) values, and dipper and nondipper status.
A total of 60 pregnant women in their third trimester were enrolled in the study. SI values were measured using a digital photoplethysmographic method (Pulse Trace System, Micro Medical Ltd., Gillingham, Kent, UK). Twenty-four-hour ambulatory blood pressure was measured by a SpaceLabs 90217 oscillometric device (SpaceLabs Inc., Redmond, WA, USA). Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and pulse pressure (PP) were recorded. Those preeclamptic women whose mean nighttime blood pressure measurements were at least 10% lower compared with mean daytime measurements were classified as dipper status, and those with a decrease of less than 10% were classified as nondipper status.
Seventeen women were preeclamptic with a dipper status, 13 women had nondipper status preeclampsia, and 30 women were normotensive. SI values were significantly higher in preeclamptic women compared with normotensive women (8.8+/-1.2 m/s vs. 5.9+/-0.8 m/s, P<0.001), but SI values of preeclamptic women with dipper status and preeclamptic women with nondipper status did not differ significantly from each other (P=0.485).
There was no significant difference in SI values between the dipper and nondipper preeclamptic groups. These results indicate that dipper and nondipper measurements may not be suitable for clinical follow-up of preeclamptic women.
本研究旨在通过比较动脉僵硬度指数（SI）值以及勺型和非勺型状态，探讨子痫前期女性勺型状态的临床相关性。
共纳入60名孕晚期孕妇。使用数字光电容积描记法（脉搏追踪系统，英国肯特郡吉灵厄姆市微医疗有限公司）测量SI值。采用SpaceLabs 90217示波装置（美国华盛顿州雷德蒙德市SpaceLabs公司）测量24小时动态血压。记录收缩压（SBP）、舒张压（DBP）、平均动脉压（MAP）和脉压（PP）。夜间平均血压测量值比白天平均测量值至少低10%的子痫前期女性被归类为勺型状态，下降幅度小于10%的女性被归类为非勺型状态。
17名女性为勺型状态的子痫前期患者，13名女性为非勺型状态的子痫前期患者，30名女性血压正常。子痫前期女性与血压正常女性相比，SI值显著更高（8.8±1.2米/秒对5.9±0.8米/秒，P<0.001），但勺型状态的子痫前期女性和非勺型状态的子痫前期女性的SI值彼此之间无显著差异（P=0.485）。
勺型和非勺型子痫前期组之间的SI值无显著差异。这些结果表明，勺型和非勺型测量可能不适用于子痫前期女性的临床随访。
