CD5阴性滤泡性淋巴瘤缓解后出现的侵袭性CD5阳性B细胞淋巴瘤，伴有独特的免疫球蛋白重链重排和易位。

Aggressive CD5-positive B-cell lymphoma after remission of CD5-negative follicular lymphoma with distinct immunoglobulin heavy chain rearrangement and translocation.

作者信息

Sonoki Takashi, Ishihara Sonoko, Uneda Shima, Hanaoka Nobuyoshi, Kurimoto Miwa, Matsuoka Hiroshi, Nakakuma Hideki

机构信息

Department of Hematology/Oncology, Wakayama Medical University, Kimi-idera 811-1, Wakayama, 641-8510, Japan.

Department of Surgical Pathology, Kumamoto University School of Medicine, Kumamoto, Japan.

出版信息

Int J Hematol. 2008 Oct;88(3):299-303. doi: 10.1007/s12185-008-0160-x. Epub 2008 Aug 30.

DOI:10.1007/s12185-008-0160-x

PMID:18758895

Abstract

We report a unique, aggressive B-cell lymphoma that developed after the long-term remission of follicular lymphoma (FL). FL cells were negative for CD5, whereas aggressive lymphoma cells were positive for CD5. In FL, one immunoglobulin heavy chain gene (IGH) allele underwent V/D/J recombination and another t(14;18)(q32;q21). In aggressive lymphoma, one IGH allele underwent D/J recombination and another translocation, but not t(14;18)(q32;q21). An aggressive lymphoma-specific D/J sequence was detected in FL tissue. Our results indicated that the two tumors arose from distinct B cells and that they existed concurrently in the same lymph node.

摘要

我们报告了一例在滤泡性淋巴瘤（FL）长期缓解后发生的独特的侵袭性B细胞淋巴瘤。FL细胞CD5呈阴性，而侵袭性淋巴瘤细胞CD5呈阳性。在FL中，一个免疫球蛋白重链基因（IGH）等位基因发生了V/D/J重排，另一个发生了t(14;18)(q32;q21)。在侵袭性淋巴瘤中，一个IGH等位基因发生了D/J重排和另一种易位，但不是t(14;18)(q32;q21)。在FL组织中检测到一种侵袭性淋巴瘤特异性的D/J序列。我们的结果表明，这两种肿瘤起源于不同的B细胞，并且它们同时存在于同一淋巴结中。