Nakayama Shizuka, Yan Lei, Sintim Herman O
Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.
J Am Chem Soc. 2008 Sep 24;130(38):12560-1. doi: 10.1021/ja803146f. Epub 2008 Aug 29.
Junction probe nucleic acid detection technology allows the amplified sensing of analytes at isothermal conditions. The addition of a second dimension to detection probes permits the use of cheap commercially available DNA processing enzymes such as restriction endonucleases to detect single nucleotide polymorphisms, SNPs.
连接探针核酸检测技术可在等温条件下对分析物进行扩增检测。在检测探针中增加第二个维度，使得能够使用诸如限制性内切酶等廉价的市售DNA处理酶来检测单核苷酸多态性（SNP）。
