Stenderup Karin, Rosada Cecilia, Dam Tomas Norman
Arhus Universitetshospital, Arhus Sygehus, Dermatologisk Afdeling, Arhus.
Ugeskr Laeger. 2008 Sep 1;170(36):2777-81.
Interleukin-20 (IL-20) is suggested as a new target in psoriasis treatment. It was first described in 2001, and the potential role of this cytokine in psoriasis was suggested because mice which were over-expressing IL-20 developed a psoriasis-like phenotype of the skin. Subsequently, IL-20 expression levels were found to be increased in psoriasis skin, and it was observed that these levels normalized upon psoriasis treatment. In the psoriasis xenograft transplantation model, administration of IL-20 to non-lesional psoriasis skin transplanted onto immune-deficient mice demonstrated that IL-20 was involved in the psoriasis induction. More interestingly, improvement of psoriasis was induced by blocking IL-20 signaling.
白细胞介素-20（IL-20）被认为是银屑病治疗的新靶点。它于2001年首次被描述，由于过度表达IL-20的小鼠出现了类似银屑病的皮肤表型，提示了这种细胞因子在银屑病中的潜在作用。随后，发现银屑病皮肤中IL-20表达水平升高，并且观察到在银屑病治疗后这些水平恢复正常。在银屑病异种移植模型中，将IL-20施用于移植到免疫缺陷小鼠身上的非皮损性银屑病皮肤表明，IL-20参与了银屑病的诱导。更有趣的是，阻断IL-20信号可诱导银屑病病情改善。
