Asensio A, Vaque-Rafart J, Calbo-Torrecillas F, Gestal-Otero J J, López-Fernández F, Trilla-Garcia A, Canton R
Department of Preventive Medicine, Hospital Universitario Puerta de Hierro. Madrid, Spain.
Euro Surveill. 2008 Jul 31;13(31):18943.
Limited information is available on the burden and epidemiology of Clostridium difficile infection (CDI) in Spain. The present report communicates the secular trends in prevalence of CDI among hospitalised patients in Spain from 1999 through 2007. Data were obtained through the EPINE study (Estudio de prevalencia de las infecciones nosocomiales en los hospitales españoles), a point prevalence study series of nosocomial infections among patients admitted to hospital in Spain. A total of 378 cases with CDI were identified. Median age was 74 years. Prevalence rates of CDI increased from 3.9 to 12.2 cases per 10,000 hospitalised patients and showed a significantly increasing secular trend from 1999 through 2007 (prevalence rate ratio per each year increment 1.09; 95% CI 1.05 - 1.14). Percentage of hospitalised patients receiving antimicrobials increased linearly from 36.0% in 1999 to 40.7% in 2007 (p <0.001) and was strongly correlated to CDI prevalence (R square = 0.73; regression coefficient =1.194, 95% CI= 1.192 - 1.196).
关于西班牙艰难梭菌感染（CDI）的负担和流行病学的信息有限。本报告阐述了1999年至2007年西班牙住院患者中CDI患病率的长期趋势。数据通过EPINE研究（西班牙医院医院感染患病率研究）获得，这是一项对西班牙住院患者医院感染进行的现患率研究系列。共识别出378例CDI病例。中位年龄为74岁。CDI的患病率从每10000名住院患者3.9例增至12.2例，且在1999年至2007年呈现出显著上升的长期趋势（每年患病率增加率为1.09；95%置信区间为1.05 - 1.14）。接受抗菌药物治疗的住院患者比例从1999年的36.0%线性增至2007年的40.7%（p<0.001），且与CDI患病率密切相关（决定系数=0.73；回归系数=1.194，95%置信区间=1.192 - 1.196）。
