常染色体显性遗传性夜间额叶癫痫中的K复合波诱发癫痫发作
K-complex-induced seizures in autosomal dominant nocturnal frontal lobe epilepsy.
作者信息
El Helou J, Navarro V, Depienne C, Fedirko E, LeGuern E, Baulac M, An-Gourfinkel I, Adam C
机构信息
AP-HP, Epileptology Unit, Neurology 1 Department, La Pitié-Salpêtrière Hospital, Paris, France.
出版信息
Clin Neurophysiol. 2008 Oct;119(10):2201-4. doi: 10.1016/j.clinph.2008.07.212. Epub 2008 Aug 31.
OBJECTIVE
To examine in detail the relations between seizures and K-complexes in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE).
METHODS
Prolonged continuous video-EEG recording and analysis of 30 seizures in an 18-year-old woman suffering from ADNFLE with a CHRNA4 gene mutation.
RESULTS
Twenty-seven of 30 recorded seizures started just after a K-complex. In nine cases a sound induced a K-complex that was immediately followed by the seizure. Most seizures preceded repetitive and brief ictal restarts.
CONCLUSIONS
Three new characteristics have been observed in this ADNFLE patient: a K-complex is almost invariably present at seizure onset; sounds trigger some seizures; ictal restarts occur often.
SIGNIFICANCE
These new observations--the presence of K-complexes at seizure onset and occurrence of sound-triggered seizures--support the view that ADNFLE seizures may be initiated by K-complexes.
目的
详细研究常染色体显性遗传性夜间额叶癫痫（ADNFLE）中癫痫发作与K复合波之间的关系。
方法
对一名患有ADNFLE且携带CHRNA4基因突变的18岁女性进行长时间连续视频脑电图记录，并分析30次癫痫发作情况。
结果
30次记录的癫痫发作中有27次在K复合波之后立即开始。在9例中，声音诱发了一个K复合波，随后立即出现癫痫发作。大多数癫痫发作之前有重复性短暂发作期重启。
结论
在该ADNFLE患者中观察到三个新特征：癫痫发作开始时几乎总是出现K复合波；声音引发一些癫痫发作；发作期重启经常发生。
意义
这些新观察结果——癫痫发作开始时存在K复合波以及声音引发癫痫发作——支持了ADNFLE癫痫发作可能由K复合波引发的观点。
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