Epping Mirjam T, Bernards René
Center for Biomedical Genetics and Cancer Genomics Centre, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Int J Biochem Cell Biol. 2009 Jan;41(1):16-20. doi: 10.1016/j.biocel.2008.07.020. Epub 2008 Aug 12.
Histone deacetylase inhibitors comprise a variety of natural and synthetic compounds, which have in common that they inhibit enzymes that mediate the removal of acetyl groups from a range of proteins, including nucleosomal histones. Histone deacetylase inhibitors have anti-cancer activities in vitro and in vivo and are used in the clinic for the treatment of advanced cutaneous T cell lymphoma. The molecular pathways targeted by these compounds are discussed with an emphasis on the effects of these compounds on retinoic acid signaling.
组蛋白脱乙酰酶抑制剂包括多种天然和合成化合物，它们的共同之处在于能够抑制介导从一系列蛋白质（包括核小体组蛋白）中去除乙酰基的酶。组蛋白脱乙酰酶抑制剂在体外和体内均具有抗癌活性，并且在临床上用于治疗晚期皮肤T细胞淋巴瘤。本文将讨论这些化合物所靶向的分子途径，重点是这些化合物对视黄酸信号传导的影响。
