大鼠肝脏微粒体和胞质溶胶中醋磺己脲还原酶活性的产后发育
Postnatal development of acetohexamide reductase activities in microsomes and cytosol of rat liver.
作者信息
Imamura Y, Torigoe M, Yanachi Y, Higuchi T, Otagiri M
机构信息
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
出版信息
Res Commun Chem Pathol Pharmacol. 1991 May;72(2):223-30.
The postnatal development of acetohexamide reductase activities in liver microsomes and cytosol were examined in male rats. The developmental pattern of acetohexamide reductase activity in liver microsomes was distinguished from that in liver cytosol. Furthermore, acetohexamide reductase activity in liver microsomes was effectively suppressed by castration, but the activity in liver cytosol was not affected by castration. These results clearly indicate that enzymes with physiologically different roles can catalyze the metabolic reduction of acetohexamide in rat liver.
对雄性大鼠肝脏微粒体和胞质溶胶中醋磺己脲还原酶活性的产后发育进行了研究。肝脏微粒体中醋磺己脲还原酶活性的发育模式与肝脏胞质溶胶中的不同。此外，去势可有效抑制肝脏微粒体中的醋磺己脲还原酶活性，但肝脏胞质溶胶中的活性不受去势影响。这些结果清楚地表明，具有生理不同作用的酶可催化大鼠肝脏中醋磺己脲的代谢还原。
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