Dadabhoy Dina, Crofford Leslie J, Spaeth Michael, Russell I Jon, Clauw Daniel J
Northwest Rheumatology Specialists, Elk Grove Village, IL 60007, USA.
Arthritis Res Ther. 2008;10(4):211. doi: 10.1186/ar2443. Epub 2008 Aug 8.
Researchers studying fibromyalgia strive to identify objective, measurable biomarkers that may identify susceptible individuals, may facilitate diagnosis, or that parallel activity of the disease. Candidate objective measures range from sophisticated functional neuroimaging to office-ready measures of the pressure pain threshold. A systematic literature review was completed to assess highly investigated, objective measures used in fibromyalgia studies. To date, only experimental pain testing has been shown to coincide with improvements in clinical status in a longitudinal study. Concerted efforts to systematically evaluate additional objective measures in research trials will be vital for ongoing progress in outcome research and translation into clinical practice.
研究纤维肌痛的人员致力于识别客观、可测量的生物标志物，这些标志物可识别易感个体、有助于诊断或与疾病活动情况平行。候选客观测量方法范围从复杂的功能性神经成像到便于门诊使用的压力疼痛阈值测量方法。我们完成了一项系统的文献综述，以评估在纤维肌痛研究中得到大量研究的客观测量方法。迄今为止，在一项纵向研究中，只有实验性疼痛测试被证明与临床状况的改善相符。在研究试验中协同努力系统评估其他客观测量方法，对于成果研究的持续进展以及转化为临床实践至关重要。
