Chao Eunice, Krewski Daniel
McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, 1 Stewart Street, Ottawa, Ont., Canada K1N 6N5.
Regul Toxicol Pharmacol. 2008 Dec;52(3):223-34. doi: 10.1016/j.yrtph.2008.08.002. Epub 2008 Aug 15.
This paper presents a graded approach to the testing of crop-derived genetically modified (GM) foods based on concern levels in a proposed risk-based classification scheme (RBCS) and currently available testing methods. A graded approach offers the potential for more efficient use of testing resources by focusing less on lower concern GM foods, and more on higher concern foods. In this proposed approach to graded testing, products that are classified as Level I would have met baseline testing requirements that are comparable to what is widely applied to premarket assessment of GM foods at present. In most cases, Level I products would require no further testing, or very limited confirmatory analyses. For products classified as Level II or higher, additional testing would be required, depending on the type of the substance, prior dietary history, estimated exposure level, prior knowledge of toxicity of the substance, and the nature of the concern related to unintended changes in the modified food. Level III testing applies only to the assessment of toxic and antinutritional effects from intended changes and is tailored to the nature of the substance in question. Since appropriate test methods are not currently available for all effects of concern, future research to strengthen the testing of GM foods is discussed.
本文基于拟议的基于风险的分类方案（RBCS）中的关注程度以及当前可用的检测方法，提出了一种对作物衍生的转基因食品进行分级检测的方法。分级方法有可能更有效地利用检测资源，减少对关注度较低的转基因食品的关注，而更多地关注关注度较高的食品。在这种拟议的分级检测方法中，被归类为一级的产品应符合基线检测要求，这些要求与目前广泛应用于转基因食品上市前评估的要求相当。在大多数情况下，一级产品无需进一步检测，或只需进行非常有限的验证分析。对于被归类为二级或更高等级的产品，根据物质类型、既往饮食史、估计接触水平、该物质的毒性先验知识以及与转基因食品意外变化相关的关注性质，可能需要进行额外检测。三级检测仅适用于对预期变化产生的毒性和抗营养作用的评估，并针对所涉物质的性质进行定制。由于目前并非所有关注的效应都有合适的检测方法，因此本文讨论了加强转基因食品检测的未来研究。
