小窝蛋白和蛋白酶体在生育三烯酚介导的心肌保护作用中（的作用）
Caveolin and proteasome in tocotrienol mediated myocardial protection.
作者信息
Das Manika, Das Samarjit, Wang Ping, Powell Saul R, Das Dipak K
机构信息
Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030-1110, USA.
出版信息
Cell Physiol Biochem. 2008;22(1-4):287-94. doi: 10.1159/000149807. Epub 2008 Jul 25.
Abstract
The effect of different isomers of tocotrienol was tested on myocardial ischemia reperfusion injury. Although all of the tocotrienol isomers offered some degree of cardioprotection, gamma-tocotrienol was the most protective as evident from the result of myocardial apoptosis. To study the mechanism of tocotrienol mediated cardioprotection, we examined the interaction and/or translocation of different signaling components to caveolins and activity of proteasome. The results suggest that differential interaction of MAP kinases with caveolin 1/3 in conjuncture with proteasome stabilization play a unique role in tocotrienol mediated cardioprotection possibly by altering the availability of pro-survival and anti-survival proteins.
摘要
研究了生育三烯酚的不同异构体对心肌缺血再灌注损伤的影响。尽管所有生育三烯酚异构体都提供了一定程度的心脏保护作用，但从心肌细胞凋亡结果来看，γ-生育三烯酚的保护作用最强。为了研究生育三烯酚介导心脏保护的机制，我们检测了不同信号成分与小窝蛋白的相互作用和/或转位以及蛋白酶体的活性。结果表明，丝裂原活化蛋白激酶与小窝蛋白1/3的差异相互作用，结合蛋白酶体稳定化，可能通过改变促生存和抗生存蛋白的可用性，在生育三烯酚介导的心脏保护中发挥独特作用。
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