Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Kuala Lumpur, Malaysia.
Nutrients. 2020 Jan 19;12(1):259. doi: 10.3390/nu12010259.
Tocotrienol (T3) is a subfamily of vitamin E known for its wide array of medicinal properties. This review aimed to summarize the health benefits of T3, particularly in prevention or treatment of non-communicable diseases (NCDs), including cardiovascular, musculoskeletal, metabolic, gastric, and skin disorders, as well as cancers. Studies showed that T3 could prevent various NCDs, by suppressing 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in the mevalonate pathway, inflammatory response, oxidative stress, and alternating hormones. The efficacy of T3 in preventing/treating these NCDs is similar or greater compared to tocopherol (TF). TF may lower the efficacy of T3 because the efficacy of the combination of TF and T3 was lower than T3 alone in some studies. Data investigating the effects of T3 on osteoporosis, arthritis, and peptic ulcers in human are limited. The positive outcomes of T3 treatment obtained from the preclinical studies warrant further validation from clinical trials.
生育三烯酚（T3）是维生素 E 的一个亚家族，以其广泛的药用特性而闻名。本综述旨在总结 T3 的健康益处，特别是在预防或治疗非传染性疾病（NCDs）方面，包括心血管、肌肉骨骼、代谢、胃和皮肤疾病以及癌症。研究表明，T3 通过抑制甲羟戊酸途径中的 3-羟基-3-甲基戊二酰基辅酶 A 还原酶（HMGCR）、炎症反应、氧化应激和激素交替，可预防各种 NCDs。与生育酚（TF）相比，T3 在预防/治疗这些 NCDs 方面的疗效相似或更好。TF 可能会降低 T3 的疗效，因为在一些研究中，TF 和 T3 的联合疗效低于单独使用 T3。关于 T3 对骨质疏松症、关节炎和消化性溃疡的人类影响的数据有限。临床前研究中 T3 治疗的积极结果需要进一步的临床试验验证。
