Coronel F David, Gallardo V Cristián, Gamargo G Claudia
Departamento de Oncología, Hospital Barros Luco Trudeau, Santiago, Chile.
Rev Med Chil. 2008 Apr;136(4):491-5. Epub 2008 Jun 16.
Primary central nervous system lymphoma (PCNSL) is a rare tumor. It occurs mainly in people aged 50 year-old or older and is more common among men. Immunodeficiency is the only established risk factor for PCNSL. We report a 35 year-old, immunocompetent woman who presented with a two weeks' history of persistent headache. Computed tomography (CT) and magnetic resonance imaging (MRI) showed an expansive lesion in the right thalamus area. Immunohistochemical studies were consistent with the diagnosis of a diffuse large B-cell non-Hodgkin 's lymphoma. The patient was treated with chemotherapy and whole brain radiotherapy, achieving complete remission of the tumor. This case is illustrative of PCNSL and contributes to update its diagnosis, management and prognosis.
原发性中枢神经系统淋巴瘤(PCNSL)是一种罕见肿瘤。它主要发生在50岁及以上人群中,且在男性中更为常见。免疫缺陷是PCNSL唯一已确定的危险因素。我们报告了一名35岁免疫功能正常的女性,她有持续两周的头痛病史。计算机断层扫描(CT)和磁共振成像(MRI)显示右丘脑区域有一个占位性病变。免疫组织化学研究结果与弥漫性大B细胞非霍奇金淋巴瘤的诊断一致。该患者接受了化疗和全脑放疗,肿瘤实现完全缓解。此病例对PCNSL具有说明意义,并有助于更新其诊断、治疗及预后情况。